Holy Trinity Church opened on April 25, 1847 and was designed by Minard LaFever. In 1867 a spire was added to the church, designed by Patrick Keely; this was removed in 1906. Holy Trinity church closed in 1957, and in 1969 St. Ann Episcopal moved to this location, changing its name to St. Ann & the Holy Trinity Church.
St. James Cathedral Basilica is the second church building to serve this parish. The first church was constructed in 1822 and was the first Roman Catholic church on Long Island. In 1852, St. James became the cathedral parish for the newly-established Diocese of Brooklyn under Bishop Loughlin. While the Diocese long planned to construct a new cathedral in Fort Greene, that plan never came to fruition and St. James has continued to serve as the cathedral church for the Diocese, although many of the Diocese's larger ceremonies are held elsewhere.
Erected in 1831 as a spin-off of Sands Street M. E. Church, this congregation was established as its own station in 1835.
Fourth church of the Sands Street Methodist Episcopal Church, the oldest Methodist Episcopal congregation in Kings County.